NSI-189 Phosphate

Research use only, not for human use.

NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies.?Its antidepressant activity is monoamine-independent.NSI-189 actively stimulated remodeling of the stroke brain.?

NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies.?Its antidepressant activity is monoamine-independent.NSI-189 actively stimulated remodeling of the stroke brain.?Parallel in vitro studies further probed this remodeling process and demonstrated that oxygen glucose deprivation and reperfusion (OGD/R) initiated typical cell death processes, which were reversed by NSI-189 treatment characterized by significant attenuation of OGD/R-mediated hippocampal cell death and increased Ki67 and MAP2 expression, coupled with upregulation of neurogenic factors such as BDNF and SCF.?These findings support the use of oral NSI-189 as a therapeutic agent well beyond the initial 6-hr time window to accelerate and enhance the overall functional improvement in the initial 6 months post stroke.

NSI189 Phosphate,NSI 189 Phosphate,NSI-189 Phosphate

Others

Other Targets

Others

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1270138-41-4

464.5

C22H33N4O5P

>98% (HPLC)

DMSO:Soluble

OP(O)(O)=O.CC(C)CCNc1ncccc1C(=O)N1CCN(Cc2ccccc2)CC1

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(-20℃)

With Ice Pack

≥ 2 years